hydroxy - PMC

Result Filters

You searched 8+ million full text articles

Try this search in 34+ million citations and abstracts

PMC Full-Text Search Results

Items: 1 to 20 of 271541

<< First< Prev

Page of 13578

Next >Last >>

Select item 96556181.

Discovery of Highly Functionalized 5-hydroxy-2H-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen

Miguel Guerra-Rodríguez, Priscila López-Rojas, Ángel Amesty, Haidée Aranda-Tavío, Yeray Brito-Casillas, Ana Estévez-Braun, Leandro Fernández-Pérez, Borja Guerra, Carlota Recio

Cancers (Basel) 2022 Nov; 14(21): 5174. Published online 2022 Oct 22. doi: 10.3390/cancers14215174

PMCID:: PMC9655618

Abstract Article PDF–9.4M

Select item 72101092.

Hydroxy-octadecenoic acids instead of phorbol esters are responsible for the Jatropha curcas kernel cake’s toxicity

Xing-Hong Wang, Jie-Qing Liu, Suiyun Chen, Yanfeng Yin, Yan Liu, Changhe Zhang

Commun Biol. 2020; 3: 228. Published online 2020 May 8. doi: 10.1038/s42003-020-0919-z

PMCID:: PMC7210109

Abstract Article PDF–4.7M

Select item 97383793.

The Efficacious Benefit of 25-Hydroxy Vitamin D to Prevent COVID-19: An In-Silico Study Targeting SARS-CoV-2 Spike Protein

Tomy Muringayil Joseph, Akshay Maniyeri Suresh, Debarshi Kar Mahapatra, Józef Haponiuk, Sabu Thomas

Nutrients. 2022 Dec; 14(23): 4964. Published online 2022 Nov 23. doi: 10.3390/nu14234964

PMCID:: PMC9738379

Abstract Article PDF–3.0M

Select item 59917834.

Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria

Aleksey I. Gerasyuto, Michael A. Arnold, Jiashi Wang, Guangming Chen, Xiaoyan Zhang, Sean Smith, Matthew G. Woll, John Baird, Nanjing Zhang, Neil G. Almstead, Jana Narasimhan, Srinivasa Peddi, Melissa Dumble, Josephine Sheedy, Marla Weetall, Arthur A. Branstrom, J. V. N. Prasad, Gary M. Karp

J Med Chem. 2018 May 24; 61(10): 4456–4475. Published online 2018 May 4. doi: 10.1021/acs.jmedchem.8b00114

Correction in:: J Med Chem. 2018 Oct 25; 61(20): 9394.

PMCID:: PMC5991783

Abstract Article PDF–2.7M

Select item 96765405.

Experimental evaluation of low-displacement compression ignited engines operating with hydroxy gas as a supplementary gaseous fuel

Natalia Duarte, Donovan Arango, Geanette Polanco, Guillermo Valencia, Jorge Duarte-Forero

Heliyon. 2022 Nov; 8(11): e11545. Published online 2022 Nov 9. doi: 10.1016/j.heliyon.2022.e11545

PMCID:: PMC9676540

Abstract Article PDF–6.1M

Select item 103417616.

Hydroxy Chalcones and Analogs with Chemopreventive Properties

Mihail Lucian Birsa, Laura G. Sarbu

Int J Mol Sci. 2023 Jul; 24(13): 10667. Published online 2023 Jun 26. doi: 10.3390/ijms241310667

PMCID:: PMC10341761

Abstract Article PDF–6.4M

Select item 64215217.

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Robert T. Jacobs, Christopher S. Lunde, Yvonne R. Freund, Vincent Hernandez, Xianfeng Li, Yi Xia, David S. Carter, Pamela W. Berry, Jason Halladay, Fernando Rock, Rianna Stefanakis, Eric Easom, Jacob J. Plattner, Louise Ford, Kelly L. Johnston, Darren A. N. Cook, Rachel Clare, Andrew Cassidy, Laura Myhill, Hayley Tyrer, Joanne Gamble, Ana F. Guimaraes, Andrew Steven, Franziska Lenz, Alexandra Ehrens, Stefan J. Frohberger, Marianne Koschel, Achim Hoerauf, Marc P. Hübner, Case W. McNamara, Malina A. Bakowski, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward

J Med Chem. 2019 Mar 14; 62(5): 2521–2540. Published online 2019 Feb 7. doi: 10.1021/acs.jmedchem.8b01854

PMCID:: PMC6421521

Abstract Article PDF–992K

Select item 95032228.

Chemosensing Properties of Coumarin Derivatives: Promising Agents with Diverse Pharmacological Properties, Docking and DFT Investigation

Sadeq M. Al-Hazmy, Mohamed Oussama Zouaghi, Jamal N. Al-Johani, Youssef Arfaoui, Rania Al-Ashwal, Bechir Hammami, Ibrahim A. Alhagri, Nabil A. Alhemiary, Naceur Hamdi

Molecules. 2022 Sep; 27(18): 5921. Published online 2022 Sep 12. doi: 10.3390/molecules27185921

PMCID:: PMC9503222

Abstract Article PDF–19M

Select item 82784849.

Selective β-Mono-Glycosylation of a C15-Hydroxylated Metabolite of the Agricultural Herbicide Cinmethylin Using Leloir Glycosyltransferases

Jihye Jung, Katharina Schmölzer, Doreen Schachtschabel, Michael Speitling, Bernd Nidetzky

J Agric Food Chem. 2021 May 19; 69(19): 5491–5499. Published online 2021 May 11. doi: 10.1021/acs.jafc.1c01321

PMCID:: PMC8278484

Abstract Article PDF–2.0M

Select item 869450910.

Ultrasound-assisted enzymatic extraction of hydroxy-sanshool compounds from the hydrodistillation residue of two Sichuan peppers: optimization, quantification and pungent taste contribution evaluation

Yuanlong Chi, Yanglong Deng, Shenghui Pu, Yao Ren, Zhifeng Zhao, Qiang He

RSC Adv. 2021 Jan 21; 11(8): 4547–4554. Published online 2021 Jan 22. doi: 10.1039/d0ra09234g

PMCID:: PMC8694509

Abstract Article PDF–792K

Select item 1012204211.

Studies on crystal growth, experimental, structural, DFT, optical, thermal and biological studies of 3-hydroxy-4-methoxybenzaldehyde single crystals

C. Smitha Rose, T. Suthan, S. Mary Delphine, C. Cynitha Wise Bell, N.C.J. Packia Lekshmi

Heliyon. 2023 Apr; 9(4): e15219. Published online 2023 Apr 7. doi: 10.1016/j.heliyon.2023.e15219

PMCID:: PMC10122042

Abstract Article PDF–4.1M

Select item 858564112.

Scientific opinion on flavouring group evaluation 414 (FGE.414): 2‐hydroxy‐4‐methoxybenzaldehyde

EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Karl‐Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Rainer Gürtler, Ursula Gundert‐Remy, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Detlef Wölfle, Matthew Wright, Romualdo Benigni, Kevin Chipman, Eugenia Cordelli, Gisela Degen, Maria Carfí, Giorgia Vianello, Wim Mennes

EFSA J. 2021 Nov; 19(11): e06883. Published online 2021 Nov 11. doi: 10.2903/j.efsa.2021.6883

PMCID:: PMC8585641

Abstract Article PDF–2.7M

Select item 847845013.

Enzymatic Synthesis of l-threo-β-Hydroxy-α-Amino Acids via Asymmetric Hydroxylation Using 2-Oxoglutarate-Dependent Hydroxylase from Sulfobacillus thermotolerans Strain Y0017

Ryotaro Hara, Yuta Nakajima, Hiroaki Yanagawa, Ryo Gawasawa, Izumi Hirasawa, Kuniki Kino

Appl Environ Microbiol. 2021 Oct; 87(20): e01335-21. Prepublished online 2021 Aug 4. Published online 2021 Sep 28. doi: 10.1128/AEM.01335-21

PMCID:: PMC8478450

Abstract Article PDF–512K

Select item 669207914.

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)‑7-Hydroxy‑N‑[(1S)‑2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)

Pauline W. Ondachi, Chad M. Kormos, Scott P. Runyon, James B. Thomas, S. Wayne Mascarella, Ann M. Decker, Hernán A Navarro, Timothy R. Fennell, Rodney W. Snyder, F. Ivy Carroll

J Med Chem. Author manuscript; available in PMC 2019 Aug 13.

Published in final edited form as: J Med Chem. 2018 Sep 13; 61(17): 7525–7545. Published online 2018 Aug 29. doi: 10.1021/acs.jmedchem.8b00673

PMCID:: PMC6692079

Abstract Article PDF–2.0M

Select item 983693815.

Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles

Martin Spinck, Carlos Piedrafita, Wesley E. Robertson, Thomas S. Elliott, Daniele Cervettini, Daniel de la Torre, Jason W. Chin

Nat Chem. 2023; 15(1): 61–69. Published online 2022 Dec 22. doi: 10.1038/s41557-022-01082-0

PMCID:: PMC9836938

Abstract Article PDF–3.0M

Select item 891432516.

Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104)

Sebastian Kwiatkowski, Maria Bozko, Michal Zarod, Apolonia Witecka, Kubra Kocdemir, Adam K. Jagielski, Jakub Drozak

J Biol Chem. 2022 Mar; 298(3): 101708. Published online 2022 Feb 10. doi: 10.1016/j.jbc.2022.101708

PMCID:: PMC8914325

Abstract Article PDF–2.1M

Select item 887635717.

Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions

Moran Frenkel-Pinter, Kaitlin C. Jacobson, Jonathan Eskew-Martin, Jay G. Forsythe, Martha A. Grover, Loren Dean Williams, Nicholas V. Hud

Life (Basel) 2022 Feb; 12(2): 265. Published online 2022 Feb 10. doi: 10.3390/life12020265

PMCID:: PMC8876357

Abstract Article PDF–2.1M

Select item 481170018.

Structure-Based Design of N-Substituted 1-Hydroxy-4-sulfamoyl-2-naphthoates as Selective Inhibitors of the Mcl-1 Oncoprotein

Maryanna E. Lanning, Wenbo Yu, Jeremy L. Yap, Jay Chauhan, Lijia Chen, Ellis Whiting, Lakshmi S. Pidugu, Tyler Atkinson, Hala Bailey, Willy Li, Braden M. Roth, Lauren Hynicka, Kirsty Chesko, Eric A. Toth, Paul Shapiro, Alexander D. MacKerell, Jr., Paul T. Wilder, Steven Fletcher

Eur J Med Chem. Author manuscript; available in PMC 2017 May 4.

Published in final edited form as: Eur J Med Chem. 2016 May 4; 113: 273–292. Published online 2016 Feb 4. doi: 10.1016/j.ejmech.2016.02.006

PMCID:: PMC4811700

Abstract Article PDF–1.6M

Select item 783956119.

Analysis of amino acids, hydroxy acids, and amines in CR chondrites

José C. Aponte, Jamie E. Elsila, Jason E. Hein, Jason P. Dworkin, Daniel P. Glavin, Hannah L. McLain, Eric T. Parker, Timothy Cao, Eve L. Berger, Aaron S. Burton

Meteorit Planet Sci. 2020 Nov; 55(11): 2422–2439. Published online 2020 Dec 16. doi: 10.1111/maps.13586

PMCID:: PMC7839561

Abstract Article PDF–424K

Select item 1078063320.

Novel Multi-Target Agents Based on the Privileged Structure of 4-Hydroxy-2-quinolinone

Ioanna Kostopoulou, Andromachi Tzani, Konstantina Chronaki, Kyriakos C. Prousis, Eleni Pontiki, Dimitra Hadjiplavlou-Litina, Anastasia Detsi

Molecules. 2024 Jan; 29(1): 190. Published online 2023 Dec 28. doi: 10.3390/molecules29010190

PMCID:: PMC10780633

Abstract Article PDF–5.2M

<< First< Prev

Page of 13578

Next >Last >>

Supplemental Content

Filter your results:

Manage Filters

PMC Images search for hydroxy

Figure 2

Representative range mass overlay ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) chromatograms of urine. (A) Extract of 1mL urine spiked with 0.3 ng of UR-144 5N hydroxy pentyl (1), JWH-122 4N hydroxy pentyl (2), JWH-122 5N hydroxy pentyl (3), JWH-210 4N hydroxy pentyl (4), JWH-210 5N hydroxy pentyl (5), UR-144 (6), JWH-122 (7) and JWH-210 (8), (B) urine sample positive to UR-144 (6) and UR-144 5N hydroxy pentyl (1); (C) Urine sample positive to JWH 122 (7) and JWH-122 4N hydroxy pentyl (2), JWH-122 5N hydroxy pentyl (3); (D) urine sample positive to JWH 210 (8) and JWH-210 4N hydroxy pentyl (4), JWH-210 5N hydroxy pentyl (5).

UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers

Medicina (Kaunas). 2020 Aug;56(8):408.
Scheme 2Synthetic Methodology to Convert Hydroxy Acid into Ester-Diacid Using Anhydride

Conversion of various hydroxy acids into ester-diacids by esterification reaction with succinic, maleic, and phthalic anhydrides using toluene as a solvent at reflux.

Poly(ester-anhydrides) Derived from Esters of Hydroxy Acid and Cyclic Anhydrides

Biomacromolecules. 2022 Aug 8;23(8):3417-3428.
Fig. 2

Representative MRM chromatograms of alverine, para hydroxy alverine and alverine-d5 (IS) in (A) double blank plasma (without analytes and IS), (B) blank plasma with working solution of IS, (C) alverine, para hydroxy alverine at LLOQ and IS, and (D) alverine and para hydroxy alverine in subject sample at C_max and IS after oral administration of 120 mg alverine capsules.

An improved LC-MS/MS method for the quantification of alverine and para hydroxy alverine in human plasma for a bioequivalence study☆

J Pharm Anal. 2017 Apr;7(2):95-102.
Fig. 7

Insulin-stimulated glucose uptake in 3T3 L1 adipocytes. Only 5- and 9-FAHFA isomers potentiate insulin-stimulated glucose transport in 3T3-L1 cells: Differentiated 3T3-L1 adipocytes were treated with FAHFAs (20 μM) or DMSO control for 24 h. Glucose transport in 3T3-L1 adipocytes treated with (A) 5-, 9-, 10-, 12-, and 13-PAHSA, palmitic acid, and 9-hydroxy stearic acid; (B) 5-, 9-, 10-, 12-, and 13-POHSA; (C) 5-, 9-, 10-, 12-, and 13-OAHSA; (D) 5-, 9-, 10-, 12-, and 13-SAHSA. E: Acyl chain constituents of FAHFAs (20 μM), palmitic acid (PA), palmitoleic acid (PO), oleic acid (OA), stearic acid (SA), and hydroxy stearic acids (5-, 9-, and 12-HSA, 20 μM). Data are the means ± SEM. n = 4–6 wells/condition. Each isomer was tested in 2–4 independent studies. ∗P < 0.05 versus DMSO; #P < 0.05 versus all other conditions. FAHFA, fatty acid esters of hydroxy fatty acid; PAHSA, palmitic acid hydroxy stearic acid; POHSA, palmitoleic acid hydroxy stearic acid; OAHSA, oleic acid hydroxy stearic acid; SAHSA, stearic acid hydroxy stearic acid.

Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs)

J Lipid Res. 2021;62:100108.